The Google API Client for Python is now considered in Alpha, which means that while it may still blow up, destroy data, and eat small kittens, I will be more surprised by such results, and less likely to say that it's a known issue. Any and all feedback you have on the library will be greatly appreciated, either via the discussion group or the issue tracker.
Just to reprise the current status, through the magic of discovery, the client library now supports the Buzz, Moderator, Latitude, Custom Search, Diactize, Translate, and Prediction APIs.
And yes, before you say it, I do owe you a blog post on the new discovery document and how it compares to WADL and how I'm not a hypocrite, but that is in process and not quite ready yet.